By Devarajan Thangadurai, Jeyabalan Sangeetha
Reflecting the interdisciplinary nature of biotechnology, this ebook covers the function of distinctive supply of polymeric nanodrugs to melanoma cells, microbial detoxifying enzymes in bioremediation and bacterial plasmids in antimicrobial resistance. It addresses sleek tendencies similar to pharmacogenomics, overview of gene expression, recombinant proteins from methylotrophic yeast, identity of novel fermentation inhibitors of bioethanol construction, and polyhydroxyalkanoate dependent biomaterials. The e-book highlights the sensible software of biotechnology and bioinformatics for bioenergy, creation of excessive worth biochemicals, modeling molecular interactions, drug discovery, and customized medication.
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Extra resources for Biotechnology and Bioinformatics: Advances and Applications for Bioenergy, Bioremediation and Biopharmaceutical Research
In certain cell types, activation of p53 by therapeutic agents may induce cell cycle arrest (and DNA repair) rather than apoptosis, thus resulting in a form of protection of cancer cells against the effects of therapy. , 2006). , 2010). Tumours containing mutant p53 are more resistant to ionizing radiation than the ones with WTp53. New anticancer strategies are currently designed either to restore inactive/suppressed WTp53 or “reactivate” mutant p53, that is, to reverse the p53 mutant phenotype into WTp53 while ensuring the approaches specifically affect tumor cells, without affecting normal cells.
Activation of caspases occurs through cleavage after an aspartate residue forms large and small subunits, which together constitute the catalytic form of the enzyme (Li and Yuan, 2008). , 1997). , 2004). , 2012d). 3 HA-CURCUMIN Curcumin (diferuloylmethane) is a low molecular weight natural polyphenolic compound found in the Indian turmeric (Curcuma longa) spice. Curcuminoids give tumeric its yellow color, with curcumin as the principal curcuminoid. Curcumin exists predominantly in two tautomeric forms- keto and enol, and the enol form is more energetically stable in solid phase and solution.
Thomas, T. ; Desai, A. ; Park, S. ; Baker, J. R. HER2 specific delivery of methotrexate by dendrimer conjugated antiHER2 mAb. Nanotech 2008, 19, 295102. ; Jemal, A. Cancer Statistics, 2012. Cancer J Clin 2012, 62, 10–29. ; Sawyer, M. B. Pharmacogenetics of paclitaxl metabolism. Crit Rev Oncol Hematol 2007, 61, 222–229. ; Hai, T. Cisplatin induces cytotoxicity through the mitogen-activated protein kinase pathways and activating transcription factor 3. Neoplasia 2010, 12, 527–538. ; Kim, C. ; Ciftci, K.