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By T. V. Astakhova, S. V. Petrova, I. I. Tsitovich, M. A. Roytberg (auth.), Nikolay Kolchanov, Ralf Hofestaedt, Luciano Milanesi (eds.)

Bioinformatics of Genome law and constitution offers chosen papers from the Fourth overseas convention on Bioinformatics of Genome legislation and constitution (BGRS), held in Novosibirsk, Russia, in July 2004. The convention used to be prepared by way of the Laboratory of Theoretical Genetics, Institute of Cytology and Genetics, Siberian department of the Russian Academy of Sciences, Novosibirsk, Russia. the fabric covers the newest subject matters in bioinformatics, together with (i) regulatory genomic sequences: databases, wisdom bases, machine research, modeling, and popularity; (ii) large-scale genome research and practical annotation; (iii) gene constitution detection and prediction; (iv) comparative and evolutionary genomics; (v) desktop research of genome polymorphism and evolution; machine research and modeling of transcription, splicing, and translation; structural computational biology: constitution- functionality association of genomic DNA, RNA, and proteins; (vi) gene networks, sign transduction pathways, and genetically managed metabolic pathways: databases, wisdom bases, laptop research, and modeling; rules of association, operation, and evolution; (vii) information warehousing, wisdom discovery and knowledge mining; and (viii) research of easy styles of genome operation, association, and evolution.

Bioinformatics of Genome law and constitution should be worthwhile for scientists occupied with simple and utilized study within the box of experimental and theoretical reviews of structure-function association of genomes, collage lecturers and scholars, and mathematicians and biologists.

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ACKNOWLEDGMENTS The work was supported by the Russian Foundation for Basic Research (grants Nos. 03-04-48469, 05-04-49111, and 03-07-90181); the Ministry of Industry, Science, and Technologies of the Russian Federation (grant No. 1501); Siberian Branch of the Russian Academy of Sciences (integration project No. 119); MCB RAS (grant No. 4); NATO (grant No. 979816); and US Civilian Research and Development Foundation for the Independent States of the Former Soviet Union (CRDF) and the Ministry of Education of Russian Federation within the Basic Research and Higher Education Program (award No.

Katokhin for helpful discussions. TRANSCRIPTION REGULATORY REGIONS DATABASE (TRRD): A SOURCE OF EXPERIMENTALLY CONFIRMED DATA ON TRANSCRIPTION REGULATORY REGIONS OF EUKARYOTIC GENES N. Kolchanov^'^*, E. Ignatieva^'^, O. Podkolodnaya\ E. Ananko^ I. Stepanenko^ ^ T. Merkulova^'^ T. Khlebodarova\ V. Merkulov\ N. Podkolodny^'^'\ D. Grigorovich^ A. Poplavsky\ A. Romashchenko^ ^ Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, prosp. ru; ^ Novosibirsk State University, ul.

1990; Sved and Bird, 1990; Bestor and Coxon, 1993). , 2(X)1). , 2004), generating strong footprints in both prokaryotic and vertebrate genomes (Xia, 2003; 2004). Here, we develop indices to capture the differential methylation-mediated substitution patterns and nucleotide triplet structures between exons and introns for gene detection. /2, andpß, where / = 1, 2, 3, and 4 corresponding to nucleotides A, C, G, and T, respectively. , intron) sequences, there is no codon structure. /2, and pß. For coding sequences, methylation will create heterogeneity in nucleotide frequencies among the three sites.

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