By Yoko Eguchi, Ryutaro Utsumi (auth.), Ryutaro Utsumi PhD (eds.)
This attention-grabbing booklet encourages many microbiologists and scholars to go into the recent global of sign transduction in microbiology. during the last decade, an enormous volume of intriguing new info at the sign transduction pathway in micro organism has been dropped at gentle. stories on those advancements were prepare during this publication, Bacterial sign Transduction: Networks and Drug ambitions. the purpose of this booklet is to supply an incentive for graduate scholars, educational scientists, and researchers within the pharmaceutical to extra elucidate the TCS networks and observe them within the look for novel drugs.
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Extra info for Bacterial Signal Transduction: Networks and Drug Targets
Marits R. Eriksson AR et al. A two-component regulatory system, pehR-pehS, controls endopolygalacturonase production and virulence in the plant pathogen Erwinia carotovora subsp carotovora. Mol Plant Microbe Interact 2000; 13:447-455. 16. Shin D. Groisman EA. Signal-dependent binding of the response regulators PhoP and PmrA to their target promoters in vivo. J Bioi Chern 2005; 280:4089-4094. 17. Chamnongpol S, Groisman EA. Acetyl phosphate-dependent activation of a mutant PhoP response regulator that functions independently of its coguate sensor kinase.
Phosphorylation of the PhoP protein promotes its binding to the pmrD promoter resulting in expression of the PmrD protein. PmrD binds to the phosphorylated form of the PmrA protein (green line), resulting in binding to the pbgP and ugd promoters and transcription of the pbgP and ugd genes. The phosphorylated PmrA protein represses transcription of the pmrD gene (red line). Fe3+ activates the PmrAlPmrB system directly. B) Model illustrating direct regulation of the pbgP and ugd genes where the PhoQ/PhoP system promotes transcription of the pbgP and ugd genes directly in response to low M g 2+ in Yersinia.
Structure ofHK/RR Complex: Signaling Pathway in PixL/Pix] System Since the full-length FixL structure containing the sensor and histidine kinase domains has been unavailable yet, it is still unclear how the conformational change in the FG loop ofthe sensor domain could be transferred to histidine kinase domain as an inhibitory signal. f-" HK from Thermotoga maritima, 1hkA (TM1359), exhibits a sequence similarity by 72% (29% identity) to FixL,73 and is expected to have a PAS sensor domain directly Structural Basis ofthe Signal Transduction in the Two-Component System C.