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By Matthew B. Nodwell, Stephan A. Sieber (auth.), Stephan A. Sieber (eds.)

ABPP method: creation and assessment, by way of Matthew B. Nodwell und Stephan A. Sieber Activity-Based Protein Profiling for common Product objective Discovery, through Joanna Krysiak und Rolf Breinbauer Photoaffinity Labeling in Activity-Based Protein Profiling, by means of Paul P. Geurink, Laurette M. Prely, Gijs A. van der Marel, Rainer Bischoff und Herman S. Overkleeft program of Activity-Based Protein Profiling to the examine of Microbial Pathogenesis, by means of William P. Heal und Edward W. Tate useful research of Protein pursuits through Metabolomic methods, by way of Yun-Gon Kim und Alan Saghatelian

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B. A. Sieber H2N CO2H NH2 NH2 N + H3C + S N CH3 NH N Methyltransferase N O Protein methyltransferase substrate Methylated substrate OH OH SAM H2N CO2H N + Protein methyltransferase substrate NH NH2 NH2 + S N Methyltransferase N N Labelled substrate O OH OH Clickable SAM analogue Fig. 10 SAM and “clickable” SAM analogs for labeling protein methyltransferase substrates pathophysiology, extensive proteomic profiling of PKMT substrates will be important for indentifying non-histone and novel histone substrates of this enzyme class.

Bioconjug Chem 15:790–798 109. Lo LC, Pang TL, Kuo CH et al (2002) Design and synthesis of class-selective activity probes for protein tyrosine phosphatases. J Proteome Res 1:35–40 110. Kumar S, Zhou B, Liang F et al (2004) Activity-based probes for protein tyrosine phosphatases. Proc Natl Acad Sci USA 101:7943–7948 111. Zechel DL, Withers SG (2000) Glycosidase mechanisms: anatomy of a finely tuned catalyst. Acc Chem Res 33:11–18 112. Tsai CS, Li YK, Lo LC (2002) Design and synthesis of activity probes for glycosidases.

1,3-Cyclohexadiones Reactive oxygen species can act as second messengers in signal transduction pathways that regulate cellular processes such as cell growth, differentiation, and migration [165–167]. It is likely that cysteine residues in proteins are the intracellular targets of oxidation, acting as redox sensors in the cell [168]. The first product in the reaction of cysteine and H2O2 is a sulfenic acid, which can then be reduced back to the thiol, or further oxidized to sulfinic or sulfonic acids [169].

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