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Structural features of microvillus growth and core-filament assembly during development have been investigated using several different species. , 1965; Chambers and Grey, 1979; Stidwill and Burgess, 1986) finds the following sequence of developmental events for brush-border growth: (1) From 5 to 10 days of incubation microvilli are sparse and the surfaces of the cells are ballooned into the lumen of the gut. (2) The ballooned apical cell surfaces are retracted as the cell surface becomes dome shaped on day 11 and remain so until the terminal web begins forming on day 19.

And Henderson, R. (1975) J. Mol. Biol. 94: 425-440. Verkleij, A. , Gemtsen, W. , Demel, R. A.. Van Deenen. L. L. , and Ververgaert, P. J. (1973) Biochim. Biophys. Acta 291: 577-581. Verkleij, A. J.. Mombers. , Leunissen-Bijvelt, J.. and Ververgaert. P. H. J. (1979) Nature Lond. 279: 162-163. THE BRUSH BORDER: A MODEL FOR STRUCTURE, BIOCHEMISTRY, MOTILITY, AND ASSEMBLY OF THE CYTOSKELETON David R. Burgess 1. INTRODUCTION The absorptive cell of the intestinal epithelium is a highly polarized columnar cell 20 p m in height whose chief function is the transport of nutrients.

67: 904-911. Edwards, H. ,Mueller. T. , and Morrison, M. (1979)Science (Wash. DC)203: 1343-1345. Elias, P. , Friend, D. , and Goerke, J. (1979)J. Histochem. Cytochem. 27: 1247-1260. Fisher, K. A. (1975)Science (Wash. DC) 190: 983-985. Fisher, K. A. (1976a)Roc. Natl. Acad. Sci. USA 73: 173-177. Fisher, K. A. (1976b)J. Cell Biol. 70: 218a. Fisher, K. A. (1978)in Electron Microscopy (W. M. ), pp. Microscopical Society of Canada, Toronto. Fisher, K. A. (1980)Annu. Rev. Physiol. 42: 261-273. Fisher, K.

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